Description

Ziprasidone 40 mg belongs to the group of antipsychotic drugs, indole derivatives. The therapeutic effect is ensured by using Ziprasidone Hydrochloride Monohydrate as the active ingredient. Due to its affinity with dopamine and serotonin receptors, the drug is used to treat schizophrenia in adults.

Pharmacological features

A positron emission tomography study of the drug’s efficacy was conducted to trace the effects on the receptors. Twelve hours after taking 40 mg of Ziprasidone, the blocking of type 2A serotonin receptors was increased by 80%. Blocking of D2 receptors was increased by more than 50%. The drug also acts on the 5HT2C, 5HT1D and 5HT1A receptors, and this action is greater than for the D2 receptors. It has weaker effects on the neuronal serotonin and norepinephrine transporters, histamine H(1)- and alpha(1)-receptors. It also has a weak effect on the muscarinic M(1) receptors.

The antipsychotic effect is due not only to the above effects, but also to the antagonistic effect on serotonin type 2A receptors (5HT2A) and dopamine type 2 receptors (D2). The effect on the nervous system is also caused by the antagonistic effect on the 5HT2C and 5HT1D receptors, the agonistic effect on the 5HT1A receptors and the inhibition of neuronal reuptake of noradrenaline and serotonin.

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Pharmacokinetics action

Ziprasidone (Geodon) reaches maximum plasma concentrations 6-8 hours after administration. Efficacy and digestibility are increased when taking the drug simultaneously with food. Therefore, it’s recommended to take the drug exactly with a meal. About 99% of the drug binds with the plasma proteins, which leads to effect on the body.

The elimination half-life is 6.6 hours on average. The excretion of the active substance from the body occurs in the following ratio: 20% in the urine and 60% in the feces. The drug is almost completely metabolized, and only less than 1% is excreted unchanged. During biotransformation, 4 active metabolites of benzisothiazol piperazine sulfoxide, benzisothiazol piperazine sulfone, ziprasidone sulfoxide and S-methylhydroziprazidone are formed.

Age and bad habits such as smoking have no effect on the action of Ziprasidone Geodon. Patients with impaired liver function have 30% higher blood concentrations than patients with a healthy liver.

Indications

Ziprasidone (Geodon) is prescribed for the treatment of schizophrenia in the form of tablets, but if oral administration is not enough, then the drug is used in the form of injections. In addition to schizophrenia, the drug has shown effectiveness in treating patients with bipolar disorder.

Contraindications

• Allergy to the underlying component and excipients.
• Congenital and established QT interval prolongation.
• Abnormal functioning of the cardiovascular system: heart failure and myocardial infarction.
• Treatment of arrhythmias with class 1 and class 3 antiarrhythmic agents.

Dosage of Ziprasidone

To get the effect of using the drug, 40 mg of Ziprasidone is prescribed twice a day. This dosage can be used as early as the third day of treatment. If there is no desired effect, you can increase the dose to 80 mg twice a day. A higher dose is not recommended because of the lack of data on the effect of the drug. The initial and maintenance dose is 20 mg twice a day. The recommended daily dose is reduced for patients with impaired liver function and if the patient is older than 65 years. No dose adjustment is required for patients with impaired renal function.

Interaction of Ziprasidone

The drug may potentiate the effects of antihypertensive drugs, so blood pressure should be monitored during such combinations. Ziprasidone Geodon may alter the pharmacokinetics of oral contraceptives, which also requires monitoring. Ketoconazole increases the blood concentration of an antipsychotic. With serotonergic agents, an adverse body reaction may occur.

Ziprasidone: weight gain

The drug may cause weight gain or loss, these phenomena are side effects with frequent occurrence. To avoid this happening before starting treatment, you need to undergo a comprehensive examination and not self-medicate.

Ziprasidone and alcohol

The drug cannot be combined with alcohol, but if the patient took a dose of alcohol before or after taking the drug, it’s necessary to monitor the condition. In case of a negative reaction after such a combination, immediately take a sorbent and call your GP.

If a severe allergic reaction develops, an antiallergic drug must be injected immediately.

Ziprasidone for anxiety

The drug eliminates the negative reactions of the body caused by schizophrenia and bipolar disorder. Ziprasidone (Geodon) is prescribed to eliminate the symptoms of anxiety caused by these very diseases. To understand the cause of the anxiety, it is necessary to undergo an examination. If the anxiety is not caused by a mental disorder, the drug may not be effective.

Ziprasidone vs. Risperidone

Ziprasidone works better on dopamine, adrenergic, and serotonin receptors, but it lacks action on alpha2-adrenergic receptors, whereas risperidone has a 55.5 index of such action. Risperidone causes an increase in body weight to a greater extent. If with Zyprazidone this index is only 0.04 kg in 10 weeks, with risperidone this figure is 2.1 kg in 10 weeks. Only the treating physician can choose which drug will be effective in each individual case.

Geodon for depression

Geodon has demonstrated its effectiveness in treating various depressive disorders, such as anxiety depression or acute depression.

Geodon vs Haldol

Both Haldol and Geodon are used to treat schizophrenia and manic-depressive episodes. However, they contain different active ingredients from the neuroleptic group.

Haldol contains the active ingredient called haloperidol. It belongs to the group of drugs called neuroleptics.

Geodon contains the active substance called Ziprasidone, which also belongs to the group of drugs called neuroleptics.

Since these are different substances, patients may have different reactions to them.

Haldol is mostly absorbed from the intestine when taken orally. The maximum concentration in the blood is reached after 3-6 hours, which means that the pronounced effect occurs after 180-360 minutes. The elimination half-life of Haldol is on average 12-37 hours.

Geodon when taken orally reaches maximum concentration in the blood within 6-8 hours, and the elimination half-life is 6.6-7 hours when taken orally. When taken 2 times/day, the equilibrium state is reached within 3 days.

So, Haldol and Geodon are neuroleptic drugs with different active substances, but Geodon is excreted by the body faster, and its saturation in the blood comes a little later. Ziprasidone, the active ingredient in Geodon, is considered a drug with a low risk of interactions.

Both Haldol and Geodon have been shown to be effective in treating schizophrenia and depressive disorders, but effectiveness may differ for each patient. A physician’s consultation is necessary before and during therapy.

Dosage of Geodon

Treatment of schizophrenia

Since the dosage of the drug depends on various factors, it must be chosen by a doctor individually for each patient.

The recommended dosage is detailed below.

Schizophrenia

For adult patients: 1 capsule, 2 times a day. Take the drug with meals, with a small amount of water.

Treatment of manic-depressive phase and depression

For adult patients: 1 capsule, 2 times daily. Take the drug with meals. Maximal dose: Do not exceed 2 capsules a day.

How long does it take for Geodon to work?

Generally, in the treatment of schizophrenia, therapy with neuroleptics is necessary for a lifetime. For the treatment of other disorders, the duration of the course and the dosage are adjusted by the doctor.

Hallucinations, disorganized thinking, and delirium can disappear during the first 1-2 weeks after taking the Geodon pill. Sometimes these symptoms do not go away completely. Symptoms continue to improve the longer ziprasidone is taken.

It may take 2-3 months before there is an obvious comprehensive improvement.

Geodon: half-life

Geodon reaches maximum blood concentrations within 6 to 8 hours when taken orally, while the elimination half-life is about 6.6 to 7 hours.

How long does Geodon stay in your system?

It may take 1 to 3 days for Geodon to be completely eliminated from your system.

Geodon overdose

If too much of the drug is taken, you may experience various symptoms of overdose, including signs of movement disorders, tremors, and anxiety. If an overdose is suspected, it is worth seeing a doctor immediately.

The dosage prescribed by your doctor may differ from the information in the instructions because the doctor will adjust the dosage individually, you should use the medicine according to the doctor’s instructions.

Geodon side effects

While taking the drug, unwanted side effects may occur, such as anxiety, movement disorders, dizziness, sedative effect, drowsiness, headache, blurred vision, nausea, vomiting, constipation, dry mouth, increased salivation, fatigue, increased appetite, fear, tightness in the throat, nightmares, seizures, coordination disorders, speech disorders.

Geodon: weight gain

Weight gain has been observed with atypical neuroleptics such as Ziprasidone. When treating Atypical Neuroleptics, weight gain should be monitored at baseline and regularly during treatment with Geodon.

What are Geodon interactions?

Geodon pill is not recommended if the patient is taking medications for heart rhythm problems, such as Antiarrhythmic drugs, Arsenic Trioxide, Halofantrine,  Mesoridazine, Thioridazine, Pimozide, Sparfloxacin.

Worth telling your doctor if you have recently taken or are currently taking medications such as Macrolide antibiotics, Lithium, Carbamazepine or Valproate, Fluoxetine, Paroxetine, Sertraline, Phenytoin, Phenobarbital, Carbamazepine. These medications may interact with Ziprasidone and change their or its effects.

Alcohol and Geodon

Alcohol can increase the side effects of Geodon and cause dizziness, drowsiness, and difficulty concentrating. Some patients may also experience impaired thinking and judgment. Alcohol should be avoided or limited during treatment with Geodon.

Geodon: food

Geodon may interact with alcohol and also cause weight gain. There are no studies according to which the drug interacts seriously with other food products, but you should consult a doctor in case of serious changes or side effects.

Geodon pill: contraindications

The drug should not be taken by patients with:

• Sensitivity to the ingredients of the drug
• ECG disorders (prolongation of the QT interval)
• Heart failure
• Arrhythmia
• Children under 10 years of age should not use the drug

According to current data, the drug Geodon should not be used during pregnancy and during lactation. The drug may adversely affect the fetus or child.

Geodon: cost

Geodon 80 mg is available in our online pharmacy for the treatment of schizophrenia, depression, and bipolar disorder. The price of Geodon in our pharmacy is fixed and corresponds to the specified. If you need or have questions, you can consult with our specialists about the price and drug interactions.