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Lexotan Bromazepam

$73.82 – $311.19

The anxiolytic pharmacological agent bromazepam lexotan is prescribed for the treatment of anxiety. Lexotan effectively deals with emotional tension, feelings of anxiety and anxiety, fear. Lexatin produces mild sedative-hypnotic, anticonvulsant, and central muscle relaxant effects. Generic name: Bromazepam. Brand name: Lexotan.

What is Lexotan?

It is a drug that has anxiolytic properties. Lexotan has a calming effect on the nervous system when taken in modest dosages. Also, it has sedative and muscle relaxing qualities when taken in large amounts. LEXOTAN contains the active ingredient bromazepam. LEXOTAN belongs to a group of medicines called benzodiazepines. They are thought to work by their action on brain chemicals. LEXOTAN is used for anxiety, tension or agitation. Anxiety or tension associated with the normal stress of everyday life usually does not require treatment with medicines.

Your doctor, however, may have prescribed LEXOTAN for another purpose. Ask your doctor if you have any questions why LEXOTAN has been prescribed for you. In general, benzodiazepines such as LEXOTAN should be taken for short periods only (for example 2 – 4 weeks). Continuous long-term use is not recommended unless advised by your doctor. This medicine may be addictive. This medicine is available only with a doctor’s prescription.

What is Bromazepam?

Bromazepam is an anxiolytic drug (tranquilizer), a benzodiazepine derivative. It has anxiolytic, sedative, hypnotic, anticonvulsant, and central myorelaxant effects. The drug reduces emotional tension, anxiety, feelings of anxiety and fear.

Indications

Bromazepam is prescribed for the following conditions:

  • Neuroses and Psychopathy (accompanied by phobias, anxiety, emotional tension, anxiety)
  • Insomnia (with neurosis and anxiety)
  • Functional psychosomatic disorders of the cardiovascular system (pseudo-stenocardia, vasospastic angina, cardialgia, arterial hypertension of emotional genesis)
  • Functional psychosomatic disorders of the respiratory system (hyperventilation, difficulty in breathing, shortness of breath)
  • Functional psychosomatic disorders of the digestive system (irritable bowel syndrome)
  • Psychosomatic disorders of the urinary and sexual system (frequent urination, dysmenorrhea, menstrual and menstrual disorders)
  • Psychogenic headache
  • Psychogenic dermatosis (diseases accompanied by itching, irritability)
  • Used as a means for premedication in anesthesiology

When taking Bromazepam (even in therapeutic doses), physical and mental dependence may develop. The risk of addiction increases in patients with a history of drug and alcohol dependence.

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Description

Description

The anxiolytic pharmacological agent bromazepam lexotan is prescribed for the treatment of anxiety.

Lexotan effectively deals with emotional tension, feelings of anxiety and anxiety, fear. Lexatin produces mild sedative-hypnotic, anticonvulsant, and central muscle relaxant effects.

Generic name: Bromazepam.

Brand name: Lexotan.

Country of manufacture: Switzerland.

Manufacturer: F. Hoffmann-La Roche, Ltd.

Anxiety

Anxiety can occur suddenly, in the form of a panic state, or develop gradually over minutes, hours or days. Anxiety can last from a few seconds to several years, although longer duration is more common with anxiety disorders. Anxiety disorders range from subtle doubt to intense panic. Human behavior during the development of anxiety disorders is individual in nature.

If, for no reason, you have strong, long-term symptoms of anxiety that are uncontrollable and interfere with everyday activities, including communication with other people, you should contact your family doctor or nurse.

If this product does not meet your needs or interests, you may want to look at Kriadex Clonazepam Drops 10 ml. Please visit this link for further information on our Anticonvulsant Drugs

Lexotanil composition:

Active substance 1 tablet
Bromazepam 3 mg / 6 mg

Indications for using Lexotan

The drug is prescribed by doctors strictly according to the indications:

  • Generalized anxiety disorder (general persistent anxiety);
  • Adaptation disorder;
  • Insomnia;
  • Violations of the vegetative system;
  • Anxiety, with chronic diseases of the central nervous system.

Other reasons for using lexotanil: increased urination, psychogenic dermatoses, mental disorders, irritable bowel syndrome.

Contraindications lexomil

  • Children under 18;
  • Pregnant women (especially 1 trimester);
  • Lactation period;
  • Hypersensitivity to Bromazepam.

It is forbidden to use Lexotan when the patient is comatose, in a state of shock, alcoholic or drug intoxication, acute respiratory failure, myasthenia gravis.

It is strongly not recommended to take bromazepam lexotan together with other sedative medications or hypnotics.

Contradictions

Lexotan 3mg and lexotan in any other dosages are not recommended for individuals who have:
• a history of benzodiazepine hypersensitivity;
• severe respiratory insufficiency, particularly chronic obstructive pulmonary disease with incipient emphysema;
• respiratory distress;
• severe hepatic insufficiency, which may lead to encephalopathy;
• sleep apnea syndrome;
• myasthenia gravis.

What Lexotan is used for?

LEXOTAN contains the active ingredient bromazepam. LEXOTAN belongs to a group of medicines called benzodiazepines. They are thought to work by their action on brain chemicals. LEXOTAN is used for anxiety, tension or agitation. Anxiety or tension associated with the normal stress of everyday life usually does not require treatment with medicines. Your doctor, however, may have prescribed LEXOTAN for another purpose. Ask your doctor if you have any questions why LEXOTAN has been prescribed for you. In general, benzodiazepines such as LEXOTAN should be taken for short periods only (for example 2 – 4 weeks). Continuous long-term use is not recommended unless advised by your doctor. This medicine may be addictive. This medicine is available only with a doctor’s prescription.

Overdose of lexotanil 3mg

In case of an overdose of bromazepam, the risk of side effects increases. Symptom s overdose:

  • Depression of the central nervous system (from drowsiness to coma);
  • Confusion of consciousness;
  • Lethargy and drowsiness;
  • Oppression of the heart or respiratory system;
  • Even death is rarely possible.

Treatment: immediate gastric lavage, administration of an absorbent agent, constant supervision of medical personnel.

Dosage and method of administration lexilium tablete

The dosage regimen is set strictly individually. The tablets are taken orally. It is recommended to start at the lowest effective dose and increase gradually. When treating at home, the average daily dosage is 1.5-3 mg 2-3 times a day. The duration of admission is 2-4 weeks, then bromazepam is gradually canceled or switched to maintenance therapy. The maximum daily dose is 60 mg per day.

Medical advice: Do not start taking lexotan 3mg without a doctor’s prescription, it may increase the risks of other diseases. Strictly follow the doctor’s recommendations, do not interrupt the course of treatment without special indications.

How often can you take Lexotan: dosage and administration

Doses of Bromazepam Lexotan should be taken on an empty stomach since the impact of food on absorption is uncertain. There is a maximum daily intake of 60mg. 3 mg twice or three times a day is the typical daily dosage for ambulatory people. When the total amount is minimal (e.g. 3 or 6 mg), it is generally preferable to administer the whole dose in the evening rather than split it up into smaller doses during the day.

Lexotan 6 mg is prescribed twice or thrice a day for the most severe patients in the hospital. The dose should be tailored to the patient’s specific needs, not based on these guidelines. There should be a steady increase in dosages for outpatient treatment. Gradual cessation of therapy is recommended. Treatment should last as little time as feasible.

The patient should be re-evaluated frequently to determine whether or not further therapy is necessary. There should be no more than a two- to four-week course of therapy, followed by six to eight weeks of gradual weaning down.

Side effects of lexotan 6mg

Organs Type of adverse reaction
Central and peripheral nervous system Drowsiness, muscle weakness, fatigue, tremors of the limbs, numbness, decreased alertness, headache, dizziness.
Digestive system The most common side effects are dry mouth or drooling. Heartburn, vomiting, nausea. Decreased appetite and weight loss. Renal dysfunction, jaundice.
Allergic reactions Skin rash or itching.
Reproductive system Decreased libido
urinary system Urinary incontinence, urinary retention and edema, impaired renal function.

Lexotan is a drug that interacts with many other drugs that act on the central nervous system, such as antidepressants, opioid analgesics, psychotropic drugs, and sedative antihistamines. It is important to follow your doctor’s instructions when using Lexotan, and if you are experiencing distressing symptoms, contact him as soon as possible.

What are the side effects of Lexotan?

The majority of adverse reactions associated with Lexotan have been associated with the central nervous system. Drunkenness, ataxia, dizziness, behavioral problems, modest increases in bilirubin, speech difficulties, sleep disturbances, disorientation, headache, depression, and nausea are all covered.

 What is lexotan lexotanil tablets used for?

Lexotan lexotanil tablets are used to treat anxiety, most often the medicine is prescribed by a psychotherapist. The tablets have a sedative effect, thereby helping to cope with insomnia or stress.

Where to buy lexotanil? How much does lexotan cost?

You can buy the medicine from a Swiss manufacturer in our online pharmacy. In Mexico, the drug is sold without a prescription.

 ¿Para qué se utiliza Lexotan?

Lexotan trata eficazmente la tensión emocional, los sentimientos de ansiedad y ansiedad, el miedo. Lexatina produce efectos sedantes-hipnóticos, anticonvulsivos y relajantes musculares centrales leves.

Otras razones para usar lexotanil incluyen: aumento de la micción, dermatosis psicógenas, trastornos mentales, síndrome del intestino irritable.

Precautions

It is important to keep an eye on patients at the beginning of therapy to ensure that the dosage and/or frequency of administration is minimized and that bromazepam does not build up in the body. Even if you take Lexotan 3mg for sleep, you have to consult with your doctor.

Alcohol and other CNS depressants should be avoided when taking LEXOTAN since the patient’s tolerance for these substances will be reduced. Concomitant usage of LEXOTAN may result in severe drowsiness, clinically meaningful respiratory and cardiovascular depression, and/or other adverse effects.
Benzodiazepines should only be administered under medical supervision to patients who have a history of alcohol or substance abuse or dependency.

Additional Information About Lexotan

Lexotan Bromazepam has several pharmaceutical forms to take into consideration. This generic can be presented as oral pills of different concentrations of the main active agents – benzodiazepines. These are brain chemicals that treat anxiety the same way as other high-price medications on the pharma market.

For example, there are Lexotan Bromazepam 3 mg, 6mg, and even 1,5 mg. Usually, the healthcare specialists prescribe the generic of medium or high benzodiazepine concentration. Lexotan 1,5 mg is produced rarely and is used only for some mild and temporary mental conditions.

Among the inactive ingredients that are presented in the anti-anxiety generic are:

  • Cellulose;
  • Magnesium stearate;
  • Iron oxide, etc.

Note that this generic is GMO and gluten-free. In combination with Bromazepam, all the inactive agents bring anxiolytic effects. It is recommended to intake the Lexotan 3mg, 6mg according to the schedule with no gaps for a better pharmaceutical result.

For example, tablets with a high concentration of benzodiazepines are used for heavy forms of anxiety and other chronic mental disorders. At the same time, doctors often treat insomnia with this generic and prescribe Lexotan 3mg for sleep.

More Recommendations for the Lexotan Administration

Besides the risk of severe side effects in case of overdosing (addiction to the drug, headaches, chronic fatigue, etc.), the patients should avoid forgetting to take the generic. If one or several doses are skipped, the accumulative effect of the active agent decreases. It means that the treatment course can be prolonged by the healthcare specialist.

  1. It is recommended to intake the Bromazepam Lexotan generic on an empty stomach in 30-60 minutes the mealtime.
  2. Pill intake should be complemented with enough water. This way the generic will be absorbed better.
  3. If the patient is afraid of forgetting Lexotan use, it is better to opt for the reminder.
  4. Form a habit to take anti-anxiety pills at the same time every day.
  5. If you use Lexotan twice a day, make sure that you have optimal breaks between intakes (for example, use the generic in the morning and in the evening).

Attention! If you missed the pill, do not double your dose. It is dangerous for your health! Consult your doctor if it is reasonable to prolong the treatment course in case 4 or more pills were missed during your anti-anxiety regimen.

Bromazepam vs. Clonazepam

Which drug to choose depends on the disease and the duration of treatment? A comparison is presented in the table.

Name

Bromazepam

Clonazepam

Indications

Neuroses and psychopathy (accompanied by phobias, anxiety, emotional tension, restlessness), insomnia (in neuroses and fear).

Epilepsy, Lennox-Gastaud syndrome, nodding seizures, atonic seizures.

Epilepsy, Lennox-Gastaud syndrome, nodding seizures, atonic seizures.

Side effects

Sleepiness, impaired attention and concentration, decreased coordination, impaired liver and kidney function, in rare cases, agitation, hallucinations, insomnia.

Dry mouth, nausea, diarrhea, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea, liver dysfunction, increased liver transaminase activity, jaundice.

Form

1.5 mg, 3 and 6 mg tablets.

Duration of treatment

Duration of treatment

No more than 8-12 weeks

2-4 weeks

Despite the similarity of action, the drugs with different active ingredients in the composition. Therefore, be sure to consult with your doctor. It is possible that some of them may not be suitable for your treatment.

Bromazepam elimination half-life

The half-life of Bromazepam – the time during which the concentration of the drug in the body is reduced by 50% – is 20.5 hours.

Bromazepam vs Xanax

Bromazepam has similar efficacy to Xanax. The two drugs are also similar in bioavailability, which is the amount of medication that reaches the site of action in the body. The higher the bioavailability, the less loss there will be in absorption and use by the body.

Name

Bromazepam

Xanax

Side Effects

Suppression of emotions, weakness, ataxia, limb tremors, muscle weakness, anterograde amnesia (with conduct disorder), depression, anxiety, irritability.

Headache, dizziness, sleep disturbance, apathy, decreased concentration, impaired memory, insomnia. Gastrointestinal tract: nausea, vomiting, liver disorders.

Addiction

Benzodiazepines can be addictive. Reducing the dose or abruptly stopping this medication can cause withdrawal syndrome.

Xanax is addictive. It also has external manifestations. The skin may become red and rash-like. The face swells, becomes puffy, and other parts of the body may also swell, including the throat and tongue. Speech in this case becomes difficult, the voice changes.

Contraindications

Patients who are elderly, weakened patients, as well as patients with impaired liver function should be prescribed lower doses. Pregnancy and lactation: Contraindicated in pregnancy and during breast-feeding.

Glaucoma, abuse of alcohol, opioid analgesics, sleeping pills and psychotropic drugs. Chronic respiratory diseases. Diseases of the liver and kidneys.

Indications

Anxiety and agitation in mental diseases, including affective disorders, schizophrenia (as part of combination therapy).

Anxiety, neuroses, sleep disorders, irritability.

Bromazepam and Xanax should only be used short term because of the risk of addiction and dependence. Use the drug strictly as prescribed by your doctor and following all recommendations listed on the prescription.

Bromazepam vs. Alprazolam for sleep

Bromazepam and Alprazolam have a lot in common. They work in the same way, can cause addiction, and can cause similar side effects if used improperly. Both drugs have a sedative effect.

Bromazepam 6 mg has a slower action and is eliminated from the body over a longer period of time than Lorazepam. This means that the effects of Bromazepam last longer than those of Alprazolam. This feature makes it possible to take Bromazepam less frequently and thereby reducing the toxic effects of the anxiolytic.

The average half-life of Alprazolam is 12-15 hours. Bromazepam is excreted for an average of 18-21 hours.

Bromazepam vs. Lorazepam

The differences and similarities between the drugs are shown in the table.

Name

Bromazepam

Lorazepam

Indications

In neuroses;

For psychopathy with anxiety, agitation, nervous tension, irritability;

For functional psychosomatic disorders;

In chronic alcoholism (withdrawal syndrome).

Lorazepam is used for short-term treatment of anxiety and insomnia due to anxiety disorder.

Half-life elimination period

20.5 hours

16 hours

Side Effects

Headaches, dizziness, weakness, impaired coordination, decreased memory and attention. Gastrointestinal: nausea, diarrhea, dry mouth.

Arterial hypotension, liver, and kidney disorders.

Weakness, apathy, decreased memory, headache, dizziness, depression, ataxia, sleep disorders. In rare cases, skin rashes.

Duration of treatment

8-12 weeks

Up to 4 weeks

Due to a longer half-life, Bromazepam’s effects are longer, so you need to take an additional tablet less often.

Does Bromazepam have a sleeping effect?

Lexotan (Bromazepam) has a hypnotic effect that promotes fast falling asleep, while increasing the duration of sleep itself, reducing the number of nighttime awakenings. The mechanism of the hypnotic effect is inhibition of the reticular formation cells of the brain stem.

Dosage

Dosage regimen is established strictly on an individual basis: 1.5-3 mg 2-3 times a day; if necessary (in hospital) the dose is increased to 6-12 mg 2-3 times a day. For children older than 1 year (if necessary) the dose is adjusted individually depending on body weight. The dose should be reduced for elderly patients, weakened patients and patients with liver dysfunction. The total duration of treatment with 3 mg/6 mg Bromazepam is no more than 8-12 weeks, including a period of gradual dose reduction.

Side effects

Consult a physician before use because the drug has side effects:

  • Neurological disorders: hallucinations, lethargy, drowsiness, fatigue, dizziness, confusion, headache.
  • Digestive disorders: dry mouth, jaundice, epigastric pain, nausea, diarrhea, vomiting, constipation.
  • Respiratory disorders: chest pain, laryngospasm.
  • Cardiovascular disorders: bradycardia, arterial hypotension.
  • Genitourinary disorders: urinary retention, menstrual disorders, decreased libido.
  • Allergic reactions: redness, itching, exanthema.
  • Other effects: rare – weight loss.

Also, the drug is contraindicated in the first trimester of pregnancy, during breastfeeding. Administration in the second and third trimesters is possible (under strict indications).

Additional information

Additional information

Quantity in a package

3 mg 30 Tabs, 3 mg 100 Tabs, 6 mg 30 Tabs, 6 mg 100 Tabs

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Kriadex

Kriadex is prescribed for patients with anxiety disorders. It has a pronounced anticonvulsant and anxiolytic effect. It is possible to prescribe the medicine for psycho-emotional agitation and to relieve withdrawal syndrome.

What does Kriadex use for?

Kriadex is an anticonvulsant, anti-epileptic, anxiolytic, sedative, and muscle relaxant used in the treatment of conditions such as absences, myoclonus, seizures, and epilepsy.

Kriadex 2mg: Dosage

The initial dosage for adult patients should be no more than 1 mg per day. In subsequent treatment, the maintenance dosage is usually 4 to 8 mg.

For the elderly, who are particularly sensitive to the effects of central depressants, the initial dosage should not exceed 0.5 mg/day because the medication may cause confusion.

For children: Due to the presence of ethanol, this product is not indicated for use in pediatrics.

How to take Kriadex 2 mg?

The dosage of the drug is indicated in general terms. In each case, the required dose is established by the doctor, based on the patient's medical history. The daily dose should be divided into 4 doses at equal intervals throughout the day.

If necessary, the doctor may prescribe a daily dosage of up to 20 mg per day. Such a dosage may be taken 2-4 weeks after the start of treatment. In the initial stages of treatment, it is recommended to prescribe the minimum dosage. The dose may be increased gradually until a maintenance dose suitable for the individual patient is found. The dosage of Kriadex 2 mg should be adapted to the needs of each individual and depends on the individual response to therapy. The maintenance dose should be determined according to clinical response and tolerability. Simultaneous administration of more than one antiepileptic drug is standard practice in the treatment of epilepsy and can be done with Kriadex. Before adding a new drug to Kriadex 2mg, it is important to note that the use of several similar drugs may result in an adverse reaction in the body.
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Lyrica (Pregabalin)

This generic is sold under different brand names. Among them are Lyrica, Lyrica CR, Pregabalin, Lyrica Pregabalin. This drug is prescribed to patients with diabetic nerve pain, seizures, fibromyalgia, etc. This is the analog medication to pills and suspension with gamma-aminobutyric acids as the main active agents.

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What is Bromazepam?

Bromazepam is an anxiolytic and sedative drug from the benzodiazepine class.

You can buy Bromazepam to treat neuropsychiatric disorders; various phobias; insomnia; anxiety; fear of surgery.

In therapeutic doses, Bromazepam predominantly has anxiolytic and sedative properties. The effect is triggered by binding to gamma-aminobutyric acid (GABA) receptors important to nerve cells.

Nerve cells in the human brain interact using mediating substances (neurotransmitters), which are emitted by one nerve cell and sensed by the next nerve cell via specific receptors.

Some neurotransmitters excite the nerve cell and thereby transmit the signal, others inhibit such signal transmission (inhibitory neurotransmitters). Adrenaline, for example, activates the nervous system and promotes its excitation, while GABA has a dampening effect.

Benzodiazepines such as Bromazepam attack GABA receptors, causing the receptor to become more sensitive to the neurotransmitter. For example, lower levels of GABA lead to more rapid sedation.

Bromazepam: side effects

The most common side effects are depression, memory loss, fatigue, sleep disturbance, headaches, difficulty concentrating, decreased ability to respond, fatigue, and hang-up effects.

Rare side effects include increased appetite, increased or decreased libido, dizziness, impaired movement coordination, nausea, diarrhea, dry mouth, and a drop in blood pressure.

Use in Pregnancy and Lactation:

While the use of bromazepam is generally contraindicated during pregnancy and lactation, it may be used under the supervision of a physician.

Adverse Reactions:

In high doses, bromazepam may cause sleepiness, dry mouth, and allergic reactions. When co-administered with other drugs that depress the central nervous system, it may have additional depressive effects. It should not be administered with alcohol. The use of bromazepam is not recommended for children under 6 years of age. It may cause drowsiness and depression of tendon reflexes, which can impair the operation of vehicles or machinery. In susceptible patients, prolonged treatment may lead to dependence. Precautions in Relation to Effects of Carcinogenesis, Mutagenesis, Impairment of Fertility: To date, no toxic effects have been reported. Bromazepam is classified as a class D medication. Dosage and Administration: Bromazepam is administered orally, and the recommended dosage will be adjusted based on individual response.
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This sedative generic is available on the market under different brand names including Fenabbott, Phenobal, Phenobarbitone, etc. The medicine is used to treat painful sensations, fever, and headaches. Additionally, Phenobarbital provides an anticonvulsant effect, so can be prescribed to patients with insomnia, epileptics, hypnotics, sedation, etc.

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Indications for use of Fenabbott

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Lyrica Half-Life

This medication obtains a rather long half-life. If you are asked about how long Lyrica stays in your system, the answer is about 6-7 hours. That is why the optimal interval between doses when it comes to severe nerve pains is 8-9 hours.

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What is Clonazepam?

Clonazepam belongs to the group of benzodiazepine derivatives. The clinical effect of the drug is a pronounced and prolonged anticonvulsant effect; it has anxiolytic, sedative, moderately pronounced hypnotic, and muscle relaxant effects. Clonazepam is prescribed as the main antiepileptic drug for the treatment of patients with newly diagnosed epilepsy.

Clonazepam Mexico is often prescribed in psychiatry and neurology. Use Clonazepam as recommended by your doctor and under his or her constant supervision.

Rivotril (clonazepam) is a benzodiazepine primarily used in the treatment of seizure and anxiety disorders. This drug may also be used to treat movement disorders, Restless Leg Syndrome, relieve trigeminal neuralgia, atypical, akinetic, myoclonic, or absence seizures, etc.

The precise mechanism by which clonazepam exerts its antiseizure and antipanic effects is unknown, although it is believed to be related to its ability to enhance the activity of GABA. Clonazepam was approved by the FDA in 1975 and it is also one of the top 200 drugs prescribed in the United States. Please consult your personal physician before you start taking any type of medication. This product is a controlled substance in Mexico and requires a doctor’s approval and prescription. The cost for the prescription and approval from the independant doctor is included in the purchase price of this medicine. This and other medicines similar will be screened for possible combinations by your approving doctor that may be harmful if taken together. here is no cost and a refund will be issued for the total price if your doctor does not approve your prescription. Generic name: Clonazepam (Spanish name, Rivotril, Ravotril, Diocam)
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Kriadex Clonazepam Drops 10 ml

Anticonvulsants
$43.31
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What is Clonazepam and what is it used for?

The active ingredient Clonazepam refers to long-acting benzodiazepines that stimulate inhibitory signals from the nervous system. Therefore, because of its predominantly anticonvulsant action, Clonazepam is used orally or parenterally as adjunctive therapy for epilepsy.

In addition to its anxiolytic, sedative, hypnotic, and muscle relaxant effects, Clonazepam has a pronounced anticonvulsant effect. Therefore, the active ingredient is used in the following diagnoses:

  • Complementary therapy for generalized epilepsy, especially in infants, children and adolescents (e.g., West syndrome, Lennox-Gasto syndrome)
  • Absent epilepsy and other myoclonic syndromes when other antiepileptic drugs are inadequate or inapplicable
  • Focal seizures in adults
  • Insomnia

Mechanism of action of the drug

Clonazepam belongs to the group of benzodiazepines. They affect the action of the physiologically most important inhibitory mediator GABA (γ-aminobutyric acid), which provides protection against excessive spontaneous activity in the nervous system.

Clonazepam binds to the allosteric benzodiazepine binding site and thus increases the affinity of the natural GABA ligand for the receptor.

Chlorine channel opening is increased, and the influx of chlorine ions into the postsynapse and hyperpolarization are enhanced, resulting in an eventual decrease in excitability. Benzodiazepines cannot increase the maximal effect of GABA and therefore have a large therapeutic range.

Absorption and half-life of Clonazepam

Clonazepam is well absorbed from the gastrointestinal tract after oral administration. Bioavailability is 71 to 76%. Tablets and oral solutions are bioequivalent in absorption, but maximum plasma concentrations are somewhat lower for tablets and are reached somewhat later, after 2-3 hours.

Clonazepam, with a half-life of 30 to 40 hours, is one of the long-acting benzodiazepines. The drug is excreted 50-70% by the kidneys and 9-30% with the feces and is reabsorbed in the intestine. Complete excretion occurs 4-10 days after oral administration of the drops.

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