Description

Lorazepam

Lorazepam is also known as a generic with other brand names (Lozam and Ativan). This medication is prescribed to patients with anxiety and trouble sleeping. It is worth noting that this drug relates to the benzodiazepine class. It means that its active agents have a direct impact on both human nerves and brains.

This way the calming effect is available in both mental and physical conditions of the patient. One more significant feature of the Lorazepam generic is the immediate anti-anxiety result together with sleep improving background.

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Lorazepam: half life

On average, the elimination half-life varies between 12-16 hours. During metabolism, Lorazepam glucuronide is formed in the body, which is 85% excreted in the urine. With impaired renal function, the elimination half-life is prolonged and there is no significant accumulation of the metabolite.

How long does Lorazepam last?

It is fully absorbed after 2-3 hours. If taken before going to bed, it begins to affect the body in 30 minutes. Mexican Lorazepam by pharmacological activity is a tranquilizer. It begins to cause a sedative effect at a low dose of 1 mg. When taken at night it helps to avoid premature awakening and long periods of falling asleep. It works all night but does not cause excessive drowsiness in the morning.

Lorazepam Pharmaceutical Form

The medication is available in the form of oral tablets and liquid for injections. The effect comes in 10-20 minutes after intake. It does not depend on the pharmaceutical form (pills or liquids) when it comes to the speed of the Lozam action.

The most average consistency of the active agents is presented in Lorazepam 2 mg. One package can consist of 40 or 80 tablets that are taken orally. Note that the dosage is better to discuss with your healthcare specialists. The daily dose for patients with anxiety can vary from one for people with troubling sleep.

Lorazepam: weight gain

In general practice, the use of the drug has no definitive data on weight gain. Gastrointestinal side effects include constipation and nausea. It may cause an allergic reaction associated with individual intolerance to the drug.

The drug should be prescribed only for a short time. Benzodiazepines may cause adverse effects on the nervous system:

• restlessness;
• agitation;
• anxiety;
• hostility;
• rage;
• hallucinations;
• psychosis.

As soon as unwanted reactions occur, therapy with the drug should be discontinued or the dosage should be adjusted. Be sure to consult a doctor at the first manifestation of adverse reactions.

Immediately discontinue the drug if pregnancy is detected. Benzodiazepine derivatives are among the drugs contraindicated during pregnancy. Use with caution in patients who are at risk of severe sedation. Lorazepam may affect the reaction when driving vehicles, so avoid work requiring concentration when taking it.

Is 5 mg of Lorazepam a lot?

A dosage of more than 3 mg is used in psychiatry if the cause of insomnia and anxiety is serious mental disorders. Even if the patient skips medication, it is not recommended to take 5 mg at 1 time. The dose should not be increased without a doctor’s approval. Discontinue the drug gradually so that withdrawal syndrome does not occur.

Lorazepam for pain

Mexican Lorazepam is used to produce a sedative effect before surgery. The drug can reduce gastrointestinal pain caused by anxiety.

Lorazepam for seizures

The anticonvulsant effect is seen when taking high doses. Lorazepam online in our pharmacy is available for the treatment of schizophrenia and depression in combination with other drugs. Therefore, if these pathologies occur with pronounced seizure attacks, the drug is able to prevent their occurrence, reduce the risk of panic attacks and other anxiety disorders.

Lorazepam Dosage for Sleep

The generic provides a sedative effect almost immediately that lasts more than 6-7 hours (up to 8 hours). It means the same time this drug stays in the human system. That is why the maximum dosage per day is 3 pills only. But most doctors recommend taking Lorazepam for sleep only once (before going to bed).

It can be explained that the generic makes people sleepy and affects their concentration properties. While taking Lorazepam 2 mg 3 times a day, you should prevent driving and riding a bike. So, if you would like to be active during the daytime, avoid using this medication (in case the main reason is to have a good sleep).

Lorazepam Dosage for Anxiety

If the generic is used for an anti-anxiety effect, it is better to take 2 pills of Lozam a day (in the morning and in the evening). The maximum daily dosage is 3 tablets. The extra pill can be taken in case of severe anxiety symptoms.

If you missed a tablet, do not use the doubled dose. The overdose can bring side effects like:

• Headache;

• Blurred vision;

• Skin itching;

• Heartburn, etc.

Inform your doctor if you have trouble breathing and loss of coordination. Your healthcare specialist can change the dosage individually to promote better effect.

Dosage of Lorazepam for sleep

For the treatment of insomnia, a minimum therapeutic dose of 1 mg half an hour before sleep should be prescribed. For serious nervous system disorders, the doctor may prescribe a dose of 3-7.5 mg per day. This amount should be divided into several doses. If the drug is used for sedative effect in surgical practice, the patient takes 1-2 mg 1-2 hours before the beginning of the operation.

Any dosage should be prescribed by a doctor. Do not self-medicate and prescribe medication without prior examination and tests. The drug should be used with caution in elderly patients. For their treatment, a dose 50% less than the standard one is used. The risk of side effects includes weakened patients. Their treatment requires condition monitoring and dosage adjustment depending on the tolerability of the drug. The drug should not be used to treat children under 12 years of age.

Other Lorazepam Side Effects

The generic causes weight gains very seldom. It can be explained by mental and physical changes in the organism that take place individually. The same story is about the common misconception about lower blood pressure with the Lozam injections or oral medication therapy.

Clonazepam vs Lorazepam

While comparing these two drugs of the same benzo class, it is necessary to mention their main differences:

• Clonazepam is taken orally only. Lorazepam is available in oral and liquid forms.

• A half-life of clonazepam is about 39-40 hours. Lorazepam has a half-life of 24-25 hours.

• Clonazepam is long-acting, while Lozam is the immediate uncontrolled substance.

To sum up, both drugs are related to benzodiazepines but differ in their half-life, and the action terms.

Does Lorazepam lower blood pressure?

The drug reduces anxiety and improves sleep, which has a positive effect on the cardiovascular system, but there is no direct antihypertensive effect. Therefore, Lorazepam (Mexico) should not be taken without prior approval from the attending physician. To reduce high BP before complex therapy, an antihypertensive drug should be used additionally.

Recommendations to Take Into Account

Do not drink alcohol while taking Lorazepam 2 mg. This medication has a direct impact on human coordination and the nervous system. Alcohol drinks can provoke dangerous side effects and hallucinations.

Additionally, consult your healthcare specialist about the duration of your treatment course. When it comes to trouble sleeping, do not take Lozam for more than 2-3 weeks. This way you will avoid addiction. Have a break time for about 7-10 days before your new medication therapy.

If you treat your anxiety with the help of Lorazepam 2 mg, it is better to have the rest period between courses every 4 weeks of generic intake. Note that you should visit your doctor every 7-10 days to monitor the results of your medication therapy and understand the progress.

Lorazepam: Instructions for Use

Generic Lorazepam 1 mg is a tranquilizer of the group of benzodiazepine derivatives. It has anxiolytic, muscle relaxant, anticonvulsant and hypnotic effects. It has a sedative effect, relieves psycho-emotional tension, reduces anxiety, fear, and restlessness.

Indications for use of anxiolytics:

• anxiety and panic states;
• depressive disorder accompanied by severe anxiety;
• neurosis;
• management of anxiety with autonomic manifestations;
• insomnia;
• relief of symptoms of alcohol withdrawal: acute agitation, tremor, threatening delirium;
• convulsive seizures, including those caused by epilepsy;
• weakening of spasms in degenerative diseases.

The drug has also found use in anesthesiology. Lorazepam is used for premedication before surgery and other painful procedures to produce a sedative effect and eliminate feelings of fear.

Although you can buy Lorazepam in many pharmacies, keep in mind that the drug is highly addictive, so it requires monitoring when taken over a long period of time.

How long does Lorazepam work?

After ingestion, the drug is quickly absorbed from the gastrointestinal tract. The bioavailability is 90%. Accumulation of maximum plasma concentration is reached after 1-3 hours.

It is metabolized in the liver mainly by oxidation into active and inactive metabolites, which ensure the duration of action of the drug.

Addiction to Lorazepam

Before you buy Lorazepam online, read the information carefully. The drug can lead to addiction.

The risk of addiction to Lorazepam increases as the dose and duration of use increases, as well as, in patients with alcoholism, drug addiction, personality disorders, phobias, and severe depression.

Signs of Lorazepam addiction:

• changes in behavior;
• the appearance of euphoria;
• sudden mood swings;
• erratic blood pressure, tachycardia;
• pale skin;
• an unsteady, unsteady gait;
• decreased appetite;
• trembling hands and feet;
• unexplained aggression;
• indifference, apathy.

A characteristic sign of habituation is disturbance of sleep-wake rhythm with night awakenings and difficulty falling asleep.

The drug is available with a doctor’s prescription. Our pharmacy offers to buy Lorazepam online together with a doctor’s prescription. It is very convenient because the cost of Lorazepam includes a prescription, and you will save time by ordering the drug on our website.

Contraindications

Despite the effectiveness of the drug, Lorazepam is contraindicated for these conditions:

• Hypersensitivity to 1,4-benzodiazepine derivatives or any substance in the drug
• Severe respiratory failure, regardless of cause;
• Severe hepatic or renal impairment;
• Myasthenia gravis;
• Glaucoma;
• Acute porphyria;
• Alcohol poisoning;
• Nocturnal apnea syndrome;
• Children under 12 years of age;
• It’s not recommended to use Lorazepam in patients with psychosis;
• Due to its lactose content, the drug should not be used in patients with hereditary lactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.

No alcoholic beverages should be consumed during treatment with Lorazepam and for 3 days after its completion.

Lorazepam for sleep

Lorazepam is an anxiolytic that is suitable for treating insomnia and anxiety. Nocturnal tranquilizers have the additional sleeping effect that Lorazepam has. However, it must be kept in mind that treatment with benzodiazepines should be limited in time and as short as possible.

Tranquilizers are needed to normalize sleep in neurotic, including anxiety, depressive disorders. Lorazepam can be purchased online in our pharmacy if your doctor has diagnosed one of the overdose conditions.

How long does Lorazepam stay in your system?

The elimination half-life is 6 to 24 hours. Lorazepam and its metabolites are excreted mostly by the kidneys with the urine, a small portion through the intestines.

Lorazepam and alcohol

According to the instructions, the combined use of alcoholic beverages and Lorazepam is strictly contraindicated. This is explained by the fact that alcohol and Lorazepam can affect the brain and nervous system, so this combination can be dangerous.

Drinking alcohol produces a state of euphoria, which is soon replaced by depression, and Lorazepam has the same effect. Thus, when using alcohol and tranquilizers, which reinforce each other’s sedative effect, it is possible to fall into a state of deep sleep, from which it is very difficult to come out on your own.

Also under the influence of alcohol the ability of the drug to cause muscle relaxation increases, and the work of the heart and respiratory organs becomes depressed. Such a condition is life-threatening.

After co-administration of alcohol and Lorazepam, it is necessary to call an ambulance immediately. An attempt may be made to induce vomiting in the victim. If consciousness is not impaired, activated charcoal should be taken as directed.

After admission to the hospital, the patient will need gastric lavage and infusion of solutions for infusion, which increase urine excretion. Such actions will help to eliminate the medication from the body. As symptomatic therapy, the antidote, Flumazenil, may be administered.

Dosage of Lorazepam for anxiety

The recommended initial dose for anxiety states is 0.5 to 3 mg per day in several doses taken orally, regardless of meals. This dose may be increased or decreased depending on the needs or age of the patient and at the discretion of the physician. You should not buy Lorazepam online unless advised by your doctor.

Mechanism of Action

Lorazepam acts on benzodiazepine receptors by increasing the sensitivity of GABA receptors to gamma-aminobutyric acid. Chlorine channels begin to open more frequently, the entrance of chlorine ions into the cells increases and, as a consequence, there is hyperpolarization of the membranes.

This decreases the excitability of neurons and inhibits their activity. The rate of nerve impulse transmission decreases. As a result, inhibition processes increase in the limbic system, which leads to an anxiolytic effect.

The effects of Lorazepam on the body are as follows:

• Reduction of anxiety levels.
• Reduction of feelings of fear, anxiety, tension, emotional excitability, intensity of experiences, increased irritability.
• Facilitation of falling asleep and improving the quality of sleep.
• Elimination of muscle spasms and tension in the muscles.
• Cramps and involuntary muscle contractions.
• Stabilization of the functions of the autonomic nervous system.
• Amnestic action (when administered intravenously).
• Antiemetic effect.

After taking the tranquilizer, there is activity, a burst of energy, a pleasant feeling of relaxation, calmness, mental and physical comfort.

Does Lorazepam cause drowsiness?

Lorazepam reduces anxiety and calms, thereby eliminating insomnia. The drug helps you fall asleep quickly and deeply, but the sleep itself is not very restorative.

Lorazepam overdose

Read the instructions for Lorazepam online and do not exceed the recommended dosage.

Symptoms of overdose: drowsiness, disorientation, slurred speech, and in severe cases, loss of consciousness, coma.

Treatment: in case of Lorazepam overdose it is necessary to take measures aimed at early excretion of the drug not yet absorbed from the body or reducing its absorption from the digestive tract (inducing vomiting, administration of activated charcoal, gastric lavage – if consciousness is preserved), monitor basic vital functions (respiration, pulse, blood pressure) and if necessary apply an appropriate symptomatic treatment. The specific antidote is Flumazenil.

Does Lorazepam cause nausea?

Lorazepam may cause gastrointestinal side effects: nausea, vomiting, diarrhea or constipation.

You should not withdraw from the treatment with Lorazepam if these side effects occur at the start of therapy, and they soon go away on their own.

If these side effects are significant, it is permissible to take medication temporarily to alleviate the condition. For example, in the case of severe nausea, a one-time symptomatic administration of Cerucal is possible, after consultation and approval by the doctor.

Lorazepam for depression

Lorazepam should only be used on a temporary and short-term basis in the treatment of sleep disorders related to anxiety. Prolonged use of Lorazepam can lead to mental and physical dependence.

Lorazepam is not an antidepressant. In case of depression, other active agents are used, and Lorazepam can only be used as an adjunctive agent strictly on the doctor’s recommendation.

What is the cost of Lorazepam?

In our online pharmacy, you can buy Lorazepam at an affordable price with a prescription from a doctor. You will always find out the cost of Lorazepam, availability, and basic information on the website.