Description

What is Zolpidem?

Zolpidem is a short-acting sleeping pill. The medicine improves the ability to fall asleep, increases the duration of sleep and improves its quality. Zolpidem (Mexico) also prolongs and deepens sleep, reduces the number of night awakenings. During therapy, it has sedative, anxiolytic, central myorelaxant and anticonvulsant effects.

The action of Zolpidem is strong and short-lived. The drug has a short half-life of about 2.4 hours. Therefore, during the day, the patient will not experience a feeling of fatigue and sleepiness.

Indications

Zolpidem tablets are used for sleep disorders: difficulty falling asleep, early or nocturnal awakenings.

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Contraindications

The drug should not be taken:

1. Patients with allergic reactions to Zolpidem and Zolpidem generic.
2. Patients with depressive disorders, mental illness, and suicide attempts.
3. Patients who use alcohol and narcotic drugs.
4. In diseases of the kidneys and liver.
5. Respiratory system disorders.
6. Pregnancy or planning pregnancy.
7. Breastfeeding.

The attending physician must be informed about all medicines, vitamins, and herbal products the patient uses, because they may interact with each other, leading to undesirable consequences.

Special Directions

While taking Zolpidem, symptoms of somnambulism may appear – the patient may get up in a drowsy state from bed and perform various actions which he does not remember in the morning.

During the treatment period, it is necessary to be cautious when driving motor transport and performing other potentially dangerous activities, which require high concentration and quick psychomotor reactions, as well as when drinking alcohol.

When prescribing the drug to patients with concomitant depressive states, it is necessary to consider the possibility of increasing suicidal tendencies. Zolpidem is not suitable for children under 18 years of age.

Interaction of Zolpidem with other medicinal products

Zolpidem should not be taken together with the following medicines:

• benzodiazepines;
• antidepressants;
• opiates;
• narcotic analgesics;
• antihistamines;
• sedatives;
• cough suppressants;
• with some antibiotics (Erythromycin, Rifampicin, Clarithromycin);
• with antifungal drugs such as Ketoconazole.

In addition, visual hallucinations have been reported when Zolpidem is used concomitantly with some antidepressants, such as Bupropion, Fluoxetine, and Sertraline.

To improve sleep, Zolpidem should not be taken with food or immediately after a meal. When taking Zolpidem, the patient should keep in mind that he or she should be in a comfortable sleeping environment for 8 hours after taking the pill, otherwise he or she may develop anterograde amnesia.

Alcohol and Zolpidem

Alcohol and sleeping pills are incompatible and cause the following changes:

• risk of sleep apnea (nocturnal apnea);
• formation of excessive sleepiness during the day;
• development of coma;
• vomiting and nausea, stomach upsets;
• difficulties with coordination of movements;
• inability to control one’s own body;
• pain and aching in the area of muscular structures;
• inability to fall asleep normally at a later time;
• nightmares in dreams.

When symptoms of poisoning occur, action should be precise and prompt:

1. Flush the patient’s stomach.
2. Turn the person sideways, so he does not choke on the vomit.
3. Make a strong tea with sugar and give a large amount to the person.

Professional medical care in this situation is provided by doctors only in a hospital setting.

How to take Zolpidem?

Zolpidem Mexico is prescribed orally before bedtime in a single dose of 10 mg.

In elderly or weakened patients, with liver dysfunction, treatment is started with a dose of 5 mg. In case of insufficient clinical effect and good tolerability, the dose may be increased to 10 mg. The maximum daily dose is 10 mg.

The course of treatment should not exceed 4 weeks. For transient insomnia, the recommended course of treatment is 2-5 days; for situational insomnia, it is 2-3 weeks.

Concise periods of treatment do not require the gradual withdrawal of the drug. In case of long-term use of Zolpidem to decrease the possibility of developing ricochet insomnia, withdrawal should be carried out gradually (reduction of daily dose first and then withdrawal of the drug).

Exceeding the dosage of the drug is contraindicated, as it may be associated with the risk of developing serious adverse effects.

Overdose

Symptoms: impaired consciousness (from confusion and lethargy to coma), ataxia, decreased blood pressure, respiratory depression.

Treatment: induction of vomiting within 1 hour after overdose, administration of activated charcoal if more than 1 hour has passed after overdose (if conscious – by mouth, if unconscious – through the probe), gastric lavage, symptomatic therapy. Flumazenil (a benzodiazepine receptor antagonist) is recommended as an antidote, but it should be remembered that antagonism with benzodiazepine receptors may lead to seizures, especially in patients with epilepsy. Dialysis is ineffective.

Does Zolpidem cause dependence?

Long-term use of Zolpidem causes tolerance to the drug, which reduces its effectiveness. It is then necessary to increase the dose, but it should be remembered that using Zolpidem for a long time may lead to addiction. Symptoms of addiction to Zolpidem can be both physical and mental.

The higher the dose and the longer the duration of treatment, the greater the risk of addiction. In addition, the risk of addiction to Zolpidem is always higher in people with a history of addiction to other drugs or alcohol. People with personality disorders are also at increased risk.

When a person addicted to Zolpidem suddenly stops taking the drug, they begin to experience withdrawal symptoms. These include anxiety, overstimulation, dizziness and headaches, muscle aches, constant tension, and extreme irritability. The symptoms that led to the prescription of Zolpidem also often reappear. This is called ricochet syndrome, which means, for example, a recurrence of insomnia.

Use of Zolpidem in pregnancy and lactation

Zolpidem should not be used during pregnancy, especially in the first trimester. Hypothermia, hypotension, and respiratory depression have been reported in infants from mothers who have taken Zolpidem in late pregnancy. Prolonged use of benzodiazepines or similar drugs in the third trimester may lead to physical dependence and withdrawal syndrome in the child. The drug also penetrates into breast milk. Therefore, the use of Zolpidem during breastfeeding is not recommended.