Description

Tylex is an analgesic opioid + analgesic non-narcotic. The pharmacological group of the drug is an antispasmodic analgesic.

When to take the drug

The main indication of Tylex is mild to moderate pain. It is allowed to drink the drug when:
injuries not related to bone damage;

• arthralgia;
• radicular syndrome;
• neuralgia;
• any pain (toothache, earache, headache).

Your doctor may also prescribe a drug to treat acute respiratory infections and flu.

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Indications

Tylex C D is used in the treatment of moderate to severe pain not relieved by peripheral analgesics (Paracetamol with Codeine has no effect on the phantom, neurogenic pain).

Codeine is indicated in situations where Paracetamol or Ibuprofen cannot manage the pain on their own.

Contraindications

The medicine should not be taken by children under 12 years of age, pregnant women, and people with a history of allergic reactions to its components.

Also, the use of the drug is prohibited for:

• Impaired breathing;
• impaired hematopoiesis;
• Liver failure (severe form);
• Renal failure (pronounced form).

Elderly people can also take this medicine but under the supervision of a doctor. The same applies to people who suffer from 12 duodenal ulcers or stomach ulcers.
If the drug is prescribed by the doctor during lactation, breastfeeding should be stopped for the period of therapy.

Contraindications

Do not take the drug in the following cases:

• Hypersensitivity to Paracetamol, Codeine, opioids, or any of the excipients
• Severe hepatic or renal impairment
• In the case of alcohol dependence
• Treatment with MAO inhibitors and up to 14 days after the end of treatment
• Respiratory insufficiency of varying degrees of severity
• In case of bronchial asthma
• The drug is not prescribed before the age of 12 years, as well as in patients with a body weight of less than 30 kg
• Adolescents under 18 years of age who have had surgery to remove the palatine or pharyngeal tonsils
• Pregnant women in their first trimester
• Women during the breastfeeding period.

The simultaneous use of other analgesics such as Buprenorphine, Nimesulide, Butorphanol, Diclofenac, Nalbuphine, Pentazocine is unacceptable.

How to take

Tylex CD is taken 1-2 tablets every 4 hours. Maximum daily dose: 8 tablets. The course of treatment with the drug as an analgesic is 5 days, as an antipyretic – 3 days.

Dosage

Tylex CD should be started with a small dose because of the presence of Codeine. It is recommended not to exceed the treatment with the drug for more than three days.

Adults: 1 tablet of Tylex at a time of intake. In case of severe pain, 2 tablets may be taken. If the pain gets worse, the daily dose can be increased to a maximum of 8 tablets. The maximum daily dose of Paracetamol, including all paracetamol-containing drugs, is 4 g and Codeine is 240 mg.

Adolescents from 12 to 18 years old. The dose depends on body weight. The dose of Codeine and Paracetamol is calculated separately. Paracetamol is taken at 10-15 mg/kg. Codeine dosage is 0.5-1 mg/kg of body weight.

Tylex is taken 1-2 capsules every 4-6 hours, but not to exceed the maximum daily dose of 60 mg/kg/day.

In elderly patients, the starting dose should be reduced by half of the usual recommended dose for adults.

Side effects

After taking the drug, the person may begin to vomit. In the epigastric region, there are painful sensations. Allergic reactions are manifested by skin itching, urticaria, swelling (quite rare). In some cases, symptoms may appear:

• hepatic/renal dysfunction;
• thrombocytopenia;
• anemia.

High dosage in case of long-term use promotes the development of drug dependence.

Side effects

In some cases, side effects occur:

• hepatitis;
• anaphylactic reactions;
• hypersensitivity reactions;
• Increased levels of liver transaminases (ALT and AST);
• dizziness;
• clonic seizures;
• paresthesias;
• renal failure;
• angioedema;
• thrombocytopenia;
• drug dependence;
• hallucinations;
• arterial hypotension.

Rarely hypersensitivity reactions occur, requiring discontinuation of treatment: shortness of breath, bronchospasm, increased sweating, BP drop up to symptoms of anaphylactic shock, and Quincke’s edema.

Severe skin reactions: acute generalized exanthema, toxic-allergic dermatosis.

Overdose

Against the background of overexcitation, sleep is disturbed. The person is nauseated, there are nagging headaches. Sometimes provoked by the development of severe respiratory failure.
In prolonged use in high dosage, there is a risk of kidney damage or development of hepatic necrosis.

Drug interaction

Prolonged use of barbiturates reduces the effectiveness of paracetamol. The risk of hepatotoxic effects increases with concomitant use:

• ethanol;
• rifampicin;
• tricyclic ADs.

It is recommended to avoid the concomitant use of expectorants and drugs containing paracetamol.

Interaction with other drugs

Tylex C D may increase or decrease the effect of some components from other pharmaceutical groups. In some cases, combining Codeine Paracetamol with certain medications increases the risk of adverse symptoms. When using the analgesic as part of complex therapy, prior consultation with your doctor is obligatory.

Peculiarities of interaction of Tylex medication with other drugs:

• When Tylex 500 is combined with indirect anticoagulants, there is a risk of internal bleeding
• Microsomal oxidation inducers in combination with Tylex may cause severe intoxication of the body
• Colestiramine-based agents reduce the effectiveness of paracetamol;
• The drug enhances the effect of sleeping pills, sedatives, and analgesics

When combined with ethanol, the risk of hepatotoxic effects of analgesics increases.

Special instructions

While taking the medication, concentration may decrease. Also, the speed of psychomotor reactions is markedly reduced. Therefore, during therapy, special care should be taken when driving.

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