Description

Vortioxetine

Vortioxetine is prescribed for the therapy of serious depressive disorders in adult patients. Its effect on the body and improvement of the condition is made possible by inhibiting serotonin transfer proteins. It has antidepressant and anxiolytic properties. It improves cognitive functions, memory, and learning ability.

Pharmacological properties and action

Vortioxetine hydrobromide showed maximum plasma concentration after 7-11 hours. The effectiveness of the drug increases in proportion to the dose. 5-20 mg of the active substance copes with a wide range of depressive and anxiety states. After the withdrawal of the drug, the risk of relapse is minimal.

Vortioxetine (Trintellix) can be taken by elderly patients. Studies have been able to obtain tolerability data in both adult patients. The drug has been shown to be effective in treating patients with severe depression and severe anxiety. The drug is suitable for the treatment of patients with a severe response to therapy. Vortioxetine generic in a dose of 10-20 mg was more effective than agomelatine in a dose of 25-50 mg.

Improvement of cognitive function was due more to the direct effect on cognitive processes than to the indirect effect through reduction of depressive state manifestations. The active substance improves the quality of life and general health. The effect of the drug persists after withdrawal.

The drug is well tolerated in short-term and long-term treatment. The drug has no effect on the quality of sleep, reduces the risk of insomnia, somnolence. The drug has no pronounced withdrawal symptoms during long-term treatment of 24-64 weeks or short-term use of 6-12 weeks. The drug does not affect changes in weight, heart rate, blood pressure. The half-life of the drug is 66 hours. Stable concentration is reached after 2 weeks.

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Vortioxetine. Weight gain

Vortioxetine does not cause weight gain.

Usage peculiarities

During the first few weeks, it’s necessary to monitor the patient’s condition because of the risk of suicidal thoughts and health hazards. It’s especially important to monitor the condition of patients who have a history of suicide attempts. The drug is prescribed with caution in patients with a history of seizures. Antidepressants increase the risk of seizures. Use the drug with caution to treat patients with mania. In rare cases, the drug may cause serotonin syndrome or neuroleptic malignant syndrome. The risk of such a condition increases when concomitantly taken with serotonergic agents.

Peculiarities of using the drug

When treating patients with suicide attempts and suicidal thoughts, the first effect is observed a few weeks after the start of therapy. Therefore, it is necessary to monitor the condition carefully at the beginning of therapy due to the increased risk of suicidal thoughts. Monitor the condition during changes in the amount of medication and immediately inform the physician as soon as changes in behavior appear.

There is a potential risk of seizures in patients with epilepsy or seizures when taking the drug. At the first manifestations of pathology, stop treatment with the drug.
Serotonin syndrome or neuroleptic malignant syndrome may occur when taking the drug. The risk of developing a condition that is life-threatening increases with concomitant administration of triptans, MAO inhibitors, antipsychotics, and dopamine antagonists. Symptoms of serotonin syndrome are agitation, hallucinations, up to coma. Tachycardia, impaired coordination of movements, hyperreflexia, gastrointestinal disturbances are possible.

The drug is prescribed with caution in patients with mania. If a manic phase develops, discontinue treatment. When taking any of the serotonergic antidepressants, gynecological bleeding, gastrointestinal hemorrhages, bruising, the purpura may occur. Therefore, the drug should be used with caution to treat patients who simultaneously take anticoagulants and drugs that affect platelets. The drug is contraindicated in patients with blood clotting disorders.

Vortioxetine dose

Vortioxetine (Trintellix) can be taken with or without food. Treatment of depressive and anxious states begins with 10 mg. After a few weeks of use, it is possible to change the dosage depending on tolerance. If the drug is well-tolerated, an increase to 20 mg per day is possible. The minimum dosage is 5 mg. When there is a decrease in the manifestations of depression and anxiety, treatment is continued for another 6 months to strengthen the therapeutic effect and eliminate the risk of relapse.

Treatment with Vortioxetine 10 mg can be abruptly withdrawn due to the absence of the risk of withdrawal syndrome. There is no need to adjust the dosage in elderly patients. When CYP2D6 inhibitors are added to the treatment regimen, the dosage of the antidepressant can be reduced. There is no data on the effects on children, so it’s not used for this age group.

How to take the drug?

Taking Hydrobromide isn’t tied to the dietary regime. The medicine is taken orally. Therapy begins with a dose of 10 mg per day. If the patient tolerates the drug well, taking into account its effect on the body and the manifestation of depression, the dose can be increased to 20 mg or reduced to 5 mg.

If symptoms of depression stop occurring, treatment is continued for 6 months to strengthen the effect and exclude a relapse. It is possible to stop treatment immediately without reducing the dose because the drug doesn’t cause withdrawal syndrome.

Elderly patients do not need to reduce the dose. There is no data on the effect of the antidepressant on children, so treatment with the drug is allowed from 18 years old.

When combined with CYP2D6 inhibitors: bupropion, quinidine, fluoxetine, paroxetine, Brintellix dose should be reduced. The dose of the drug is adjusted if the patient takes rifampicin, carbamazepine, phenytoin. Keep out of reach of children.

Vortioxetine. Side effects

The drug is characterized by moderate minimal manifestations of adverse reactions, which most often appear in the first two weeks of therapy and do not lead to withdrawal of the drug.

Vortioxetine Hydrobromide may cause the following reactions:

• nausea;
• decreased appetite;
• abnormal dreams;
• dizziness;
• blushing;
• diarrhea, constipation, vomiting;
• itching;
• sweating at night.

There are no data on an overdose of the drug. When taking a dose greater than the recommended one, the manifestation of adverse reactions increases. Such a condition is treated symptomatically.

Vortioxetine. Price

You can buy Vortioxetine online in our online pharmacy. The price of Vortioxetine depends on the dosage of the drug. On this page, you can order Vortioxetine 10mg in a quantity of 14 or 28 tablets.

Contraindications, side effects, overdose

The drug shouldn’t be taken if the body is sensitive to the main or additional components. Combinations with MAO or selective MAO-A inhibitors are unacceptable. The drug has an adverse effect on the fetus; therefore, it is contraindicated in pregnancy. It should not be taken during lactation.

When taking it continuously, the following adverse reactions are possible:

– decreased appetite;

– abnormal dreams;

– bruxism;

– nausea, gastrointestinal disorders;

– tooth, sweating.

When taking 40-75 mg of the drug, nausea, dizziness, diarrhea, itching, drowsiness occurs. Overdose is treated symptomatically. It’s recommended to carry out therapy in a medical facility, seek help with the first symptoms.

Brintellix is an antidepressant characterized by direct modulation of receptor activity, inhibiting serotonin transporters. Vortioxetine is the active ingredient of the drug. It is an antagonist for receptors 5-HT3, 5-HT7 and 5-HT1D. For 5-HT1B, 5-HT1A receptors it has an agonist effect. It is characterized by inhibition of 5-HT transporters. It acts on serotonin, norepinephrine, dopamine, histamine, acetylcholine, GABA and glutamate. For these systems the active substance is a modulator of neurotransmission.

Pharmacological effect, pharmacokinetics, indications

Brintellix 10 mg due to the peculiarities of the active substance has the following effects:

• antidepressant;
• anxiolytic;
• improves cognitive function, memory.

A study involving 6,700 patients proved the effectiveness of the drug. While taking the drug, the risk of relapse of depression was halved in the group that took the drug compared to placebo. The drug improves the condition of patients who have depressive disorders of more than 30 points on the MADRS scale. It is effective in treating anxiety disorders with more than 20 points on the HAM-A scale. Despite its antidepressant effect, there is no drowsiness or insomnia while taking it.

After oral intake, the drug is well absorbed. The full effect develops 7-10 hours after ingestion. It has a bioavailability of 75%. Food intake does not influence the effect. The active substance 97% is bound to plasma proteins. Metabolism occurs in the liver. The half-life is long and lasts for 33-66 hours.

Brintellix medication is prescribed to treat depression and prevent relapses. In addition to eliminating the acute condition, it is used for maintenance therapy.

Contraindications

1. Brintellix 10 mg tablets should not be used if the patient has any sensitivity to the active ingredient or the individual components of the formulation.
2. Non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors must not be combined with the drug.
3. Do not drink alcohol while taking this medicine.
4. It is not recommended to treat children less than 18 years of age due to the lack of a pronounced therapeutic effect and a high risk of increased adverse reactions.
5. It is not recommended to use during pregnancy due to toxic effects on the fetus.

Dosage of Brintellix

Medication Brintellix is taken in a dose of 10 mg. To get the desired effect, it is enough to take once a day. The treatment should be prescribed by a doctor and strictly monitor the condition of the patient. Depending on the course of the disease, the dose may be reduced to 5 mg or increased to 20 mg.

When the patient’s condition improves, the treatment should be carried out for another 6 months to avoid a relapse. It is possible to stop taking it abruptly. There is no need to gradually reduce the amount of the drug.

Treatment of patients older than 65 years should be started with a dose of 5 mg. The amounts of drug for this group of patients should not exceed 10 mg. Patients with impaired renal and hepatic function do not need to change the dose.

Brintellix side effects

• New antidepressants brintellix may cause nausea
• Abnormal dreams
• Dizziness
• Diarrhea, constipation, vomiting
• Itching
• Mydriasis
• Hyperemia of the face

Brintellix for depression

Patients with a severe course of depression may be at risk of suicidal thoughts, so at the beginning of treatment the patient’s condition should be monitored. In the middle of treatment, the condition improves and by the end of therapy, suicidal thoughts disappear. The duration of treatment is prescribed only by a doctor on the basis of a full examination and evaluation of the condition, the body’s reaction to the drug and its effectiveness. The standard dose of 10 mg is adjusted depending on the condition.

Brintellix for anxiety

The drug is effective for all symptoms that occur during depression. The state of anxiety will decrease dramatically after the start of treatment and will completely disappear by the end of the course. The drug is used to treat depression and all accompanying conditions. If anxiety is one of the symptoms, in order to prescribe the drug, it is necessary to undergo a comprehensive study to identify the cause of the condition. Anxiety is treated with a standard dose of 10 mg once a day. It is possible to change the dose depending on the patient’s condition, but only with a comprehensive analysis of the condition.

How long does Brintellix work?

The drug is characterized by its long action and its slow development. The concentration in blood plasma reaches a peak after 7-10 after intake. Long-term therapy with the drug reduces the risk of acute reappearance of depression. Therefore, to achieve the maximum effect after improvement, the drug is taken for another 6 months.

Brintellix drug interaction

The drug should be taken with caution together with anticoagulants and antiaggregants because of the risk of bleeding. Lithium, tryptophan is also not recommended to combine with an antidepressant. It is forbidden to combine the drug with monoamine inhibitors. A pause of 14 days should be observed between the two groups of drugs. It is not advisable to combine with moclobemide, linezolid, selegiline, rasagiline, but if there is such a need, strictly monitor the patient’s condition. Combination with St. John’s wort may increase the negative reaction of the body. CYP2D6 metabolizers do not affect the action of the drug. Before starting treatment, be sure to tell the doctor about all the drugs taken by the patient to avoid adverse reactions.